The practical procedure for a preparation of 1-chloroalkyl p-tolyl sulfoxides in high optically active form: A very short synthesis of optically active disparlure
作者： Tsuyoshi Satoh , Teruhiko Oohara , Yoshiko Ueda , Koji Yamakawa
DOI: 10.1016/S0040-4039(00)80083-0
关键词: Alkyl 、 Optically active 、 Organic chemistry 、 Aliphatic compound 、 Enantiomer 、 Chemistry 、 Potassium carbonate 、 Dichloromethane 、 Sulfoxide
摘要: Abstract A chlorination of optically active alkyl p-tolyl sulfoxides with N-chlorosuccinimide in dichloromethane the presence potassium carbonate afforded 1-chloroalkyl 87–94% ee (88–94% chemical yields). The chloroalkyl sulfoxide was applied to a synthesis (+)-disparlure.
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