Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates.
作者： Francesca Cirulli , Nadia Francia , Alessandra Berry , Luigi Aloe , Enrico Alleva
DOI: 10.1016/J.NEUBIOREV.2008.09.001
关键词: Psychology 、 Maternal deprivation 、 Neuroscience 、 Neurotrophic factors 、 Neurotrophin 、 Central nervous system 、 Psychopathology 、 Brain-derived neurotrophic factor 、 Mood disorders 、 Nerve growth factor
摘要: Early adverse events can enhance stress responsiveness and lead to greater susceptibility for psychopathology at adulthood. The epigenetic factors involved in transducing specific features of the rearing environment into stable changes brain behavioural plasticity have only begun be elucidated. Neurotrophic factors, such as nerve growth factor (NGF) brain-derived neurotrophic (BDNF), are affected by play a major role development trophism neuronal networks cognitive function mood disorders. In addition central nervous system, these effectors produced peripheral tissues, thus being position integrate response external challenges. this paper we will review data, obtained from animal models, indicating that early maternal deprivation affect neurotrophin levels. Maladaptive or repeated activation NGF BDNF, during postnatal life, may influence sensitivity adulthood increase vulnerability stress-related psychopathology.
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