New Advances in Fatty Acids as Antimalarial, Antimycobacterial and Antifungal Agents
作者： N.M. Carballeira
DOI: 10.1016/J.PLIPRES.2007.10.002
关键词: INHA 、 Biochemistry 、 Mycobacterium tuberculosis 、 Antimycobacterial 、 Antifungal 、 Antimalarial Agent 、 Enzyme inhibition 、 Reductase 、 Plasmodium falciparum 、 Biology
摘要: Abstract This review deals with the most recent findings on antimalarial, antimycobacterial, and antifungal properties of fatty acids, particular emphasis novel marine acids. The first section some background literature what has been latest developments respect to acids as antimalarial agents importance enzyme inhibition, in inhibition enoyl-ACP reductase (FabI) Plasmodium falciparum , principal agent responsible for malaria. also emphasizes research very long-chain Δ5,9 from sponges. second antimycobacterial activity (InhA) Mycobacterium tuberculosis activity. inhibitory activities against InhA well that α-methoxylated are discussed. topoisomerase I inhibitors its connection cancer is reviewed. last part review, section, N -myristoyltransferase (NMT) but acetylenic considered.
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sci-hub.se 参考文章(74)
Bonifaz A, Canseco P, Araiza J, Otomycosis: clinical and mycological study of 97 cases. Revue de laryngologie - otologie - rhinologie. ,vol. 127, pp. 251- 254 ,(2006)
C.A. Langner, J.K. Lodge, S.J. Travis, J.E. Caldwell, T Lu, Q Li, M.L. Bryant, B Devadas, G.W. Gokel, G.S. Kobayashi, 4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. Journal of Biological Chemistry. ,vol. 267, pp. 17159- 17169 ,(1992) , 10.1016/S0021-9258(18)41908-4
R. Wood, T. Lee, Metabolism of 2-hexadecynoate and inhibition of fatty acid elongation. Journal of Biological Chemistry. ,vol. 256, pp. 12379- 12386 ,(1981) , 10.1016/S0021-9258(18)43283-8
A Chakrabarti, MR Shivaprakash, Microbiology of systemic fungal infections. Journal of Postgraduate Medicine. ,vol. 51, pp. 16- ,(2005)
Pullarkat Krishnan Raju, Raymond Reiser, Inhibition of Stearoyl Coenzyme A Desaturase by Sterculate in Mouse Liver Microsomes Journal of Biological Chemistry. ,vol. 247, pp. 3700- 3701 ,(1972) , 10.1016/S0021-9258(19)45198-3
Pullarkat K. Raju, Raymond Reiser, Hepatic Stearoyl-CoA Desaturase Activity in Mice as Affected by Early Postnatal Dietary Cyclopropene Fatty Acids The Journal of Nutrition. ,vol. 103, pp. 904- 907 ,(1973) , 10.1093/JN/103.6.904
Yuko Yonezawa, Tsuyoshi Tsuzuki, Takahiro Eitsuka, Teruo Miyazawa, Takahiko Hada, Keisuke Uryu, Chikako Murakami-Nakai, Hiroshi Ikawa, Isoko Kuriyama, Masaharu Takemura, Masahiko Oshige, Hiromi Yoshida, Kengo Sakaguchi, Yoshiyuki Mizushina, Inhibitory effect of conjugated eicosapentaenoic acid on human DNA topoisomerases I and II. Archives of Biochemistry and Biophysics. ,vol. 435, pp. 197- 206 ,(2005) , 10.1016/J.ABB.2004.12.011
John B. MacMillan, Tadeusz F. Molinski, Majusculoic Acid, a Brominated Cyclopropyl Fatty Acid from a Marine Cyanobacterial Mat Assemblage Journal of Natural Products. ,vol. 68, pp. 604- 606 ,(2005) , 10.1021/NP049596K
Néstor M Carballeira, Denisse Ortiz, Keykavous Parang, Soroush Sardari, None, Total Synthesis and in Vitro-Antifungal Activity of (±)-2-Methoxytetradecanoic Acid Archiv Der Pharmazie. ,vol. 337, pp. 152- 155 ,(2004) , 10.1002/ARDP.200300824
L M Kumaratilake, B S Robinson, A Ferrante, A Poulos, Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids: in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei. Journal of Clinical Investigation. ,vol. 89, pp. 961- 967 ,(1992) , 10.1172/JCI115678