Prospective Studies Exploring the Possible Impact of an ID3 Polymorphism on Changes in Obesity Measures.

摘要: OBJECTIVE Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases BMI visceral mass. We hypothesized that ID3 missense variant (rs11574-A) would lead to an increase over time mass, BMI, waist circumference (WC), waist-hip ratio (WHR) humans. METHODS The genotyped study populations included Obesity Research Group - Genetics (ORGGEN) cohort, a cohort men with obesity (N = 716) randomly selected (N = 826) from Danish draft register who were examined at mean ages 20 46 years, Inter99 (N = 6,116) Health2006 (N = 2,761) cohorts, two population-based samples middle-aged people, followed up after 5 years. RESULTS In meta-analyses all data, no association was found between rs11574-A changes WC, WHR, or cross-sectional (N = 10,359, β: -0.16 kg/m2 per allele, 95% CI: -0.30 -0.01, P = 0.033) (N = 4,188, -0.52 -1.03 P = 0.046). CONCLUSIONS No consistent impact genetic distribution three cohorts.