The clinicopathological spectrum of Rosenthal fibre encephalopathy and Alexander’s disease: a case report and review of the literature

摘要: Alexander’s disease is a leucodystrophy that usually presents in early childhood, but can infrequently arise adults. It characterised pathologically by megalencephaly, demyelination, and the presence of numerous Rosenthal fibres. Most cases have been shown to be due mutations gene encoding glial fibrillary acidic protein. In rare instances, fibres found at autopsy patients who suffered protracted debilitating systemic illnesses, some with associated brain stem signs, very instances no apparent neurological abnormality. The term “Rosenthal fibre encephalopathy” used distinguish these from those disease. We report first case encephalopathy young man AIDS, review literature.