Dose-dependent, amphetamine-induced changes in permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.
作者： Raman Sankar , Steven Cole , David Wellmeyer , Floyd R. Domer
DOI: 10.1016/0014-4886(80)90184-3
关键词: Blood–brain barrier 、 Dose dependence 、 Pharmacology 、 Blood pressure 、 Human serum albumin 、 Permeability (electromagnetism) 、 Chemistry 、 Amphetamine
摘要: The permeability of the blood-brain barrier to 131I-radioiodinated human serum albumin can be changed by acute administration amphetamine intravenously. In normotensive rats (WKY), response was dose dependent and biphasic. increased doses 7.5 mg/kg or less decreased 15 30 mg/kg. in spontaneously hypertensive (SHR) quite different. greater saline-treated animals than animals. Doses as much 5 caused an increase permeability, but found At from mg/kg, there were no significant changes barrier. There a high correlation between change blood pressure
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