The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils.

摘要: LPS stimulates human monocytes and neutrophils to produce IL-1 beta receptor antagonist (IL-1ra). IL-10 has been shown inhibit LPS-induced production in monocytes. The objective of these studies was examine the effects on monocyte neutrophil IL-1ra protein mRNA compare it beta. markedly inhibited both cell types. alone induced with a low level production. Furthermore, led enhanced levels at 2 6 h 4-16 h, but there no increase 24 or later. In did not stimulate augment mRNA. These net resulted an ratio inflammatory cells may be important modulation biologic responses IL-1.