Structural and mechanistic insights into mechanoactivation of focal adhesion kinase
作者： Magnus Sebastian Bauer , Fabian Baumann , Csaba Daday , Pilar Redondo , Ellis Durner
关键词: Focal adhesion 、 Biophysics 、 Force spectroscopy 、 Cytoplasm 、 Cell 、 Protein kinase domain 、 Chemistry 、 Cell adhesion 、 Mechanobiology 、 Molecular dynamics
摘要: … focal adhesions without compromising functionality. Our findings strongly support that forces in focal adhesions … conformational changes, which in turn, trigger focal adhesion signaling. …
sci-hub.se 参考文章(37)
Daniel Lietha, Xinming Cai, Derek F.J. Ceccarelli, Yiqun Li, Michael D. Schaller, Michael J. Eck, Structural Basis for the Autoinhibition of Focal Adhesion Kinase Cell. ,vol. 129, pp. 1177- 1187 ,(2007) , 10.1016/J.CELL.2007.05.041
William L. Jorgensen, Jayaraman Chandrasekhar, Jeffry D. Madura, Roger W. Impey, Michael L. Klein, Comparison of simple potential functions for simulating liquid water The Journal of Chemical Physics. ,vol. 79, pp. 926- 935 ,(1983) , 10.1063/1.445869
In Suk Joung, Thomas E. Cheatham, Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations Journal of Physical Chemistry B. ,vol. 112, pp. 9020- 9041 ,(2008) , 10.1021/JP8001614
Thorsten Hugel, Matthias Rief, Markus Seitz, Hermann E. Gaub, Roland R. Netz, Highly stretched single polymers: atomic-force-microscope experiments versus ab-initio theory. Physical Review Letters. ,vol. 94, pp. 048301- 048301 ,(2005) , 10.1103/PHYSREVLETT.94.048301
Derek F. J. Ceccarelli, Hyun Kyu Song, Florence Poy, Michael D. Schaller, Michael J. Eck, Crystal Structure of the FERM Domain of Focal Adhesion Kinase Journal of Biological Chemistry. ,vol. 281, pp. 252- 259 ,(2006) , 10.1074/JBC.M509188200
Jun Yin, Alison J Lin, David E Golan, Christopher T Walsh, Site-specific protein labeling by Sfp phosphopantetheinyl transferase Nature Protocols. ,vol. 1, pp. 280- 285 ,(2006) , 10.1038/NPROT.2006.43
Julia L Zimmermann, Thomas Nicolaus, Gregor Neuert, Kerstin Blank, Thiol-based, site-specific and covalent immobilization of biomolecules for single-molecule experiments Nature Protocols. ,vol. 5, pp. 975- 985 ,(2010) , 10.1038/NPROT.2010.49
Victor W Wong, Kristine C Rustad, Satoshi Akaishi, Michael Sorkin, Jason P Glotzbach, Michael Januszyk, Emily R Nelson, Kemal Levi, Josemaria Paterno, Ivan N Vial, Anna A Kuang, Michael T Longaker, Geoffrey C Gurtner, Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nature Medicine. ,vol. 18, pp. 148- 152 ,(2012) , 10.1038/NM.2574
Jeffrey L. Hutter, John Bechhoefer, Calibration of atomic‐force microscope tips Review of Scientific Instruments. ,vol. 64, pp. 1868- 1873 ,(1993) , 10.1063/1.1143970
H.-B. Wang, M. Dembo, S. K. Hanks, Y.-l. Wang, Focal adhesion kinase is involved in mechanosensing during fibroblast migration Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 11295- 11300 ,(2001) , 10.1073/PNAS.201201198