Histopathologic and Histomorphometric Analysis of Irradiation Injury in Bone and the Surrounding Soft Tissues of the Jaws
作者： Marcos Martins Curi , Camila Lopes Cardoso , Heliton Gustavo de Lima , Luiz Paulo Kowalski , Manoela Domingues Martins
DOI: 10.1016/J.JOMS.2015.07.009
关键词: Adipose tissue 、 Soft tissue 、 Hypocellularity 、 Medicine 、 Bone tissue 、 Bone marrow 、 Fibrosis 、 Osteoradionecrosis 、 Pathology 、 Periodontium
摘要: Purpose Surgery of irradiated tissue has an increased complication rate because the development hypovascular, hypocellular, and hypoxic tissue. This study was undertaken to perform histopathologic histomorphometric analyses irradiation injury in bone surrounding soft tissues. Material Methods The findings 40 human mandibular bones specimens obtained from different patients who underwent surgical procedures for treatment osteoradionecrosis jaws were reviewed. Results Histopathologic examination showed 7 processes following order appearance: hyperemia, endarteritis, thrombosis, cell loss, hypovascularity, increase fat marrow cavity, fibrosis. Histomorphometric analysis significant hypocellularity ( P = .007), hypovascularity Conclusion These results that radiation injuries affect However, irradiation-induced injuries, such as cellular loss (hypocellularity) fibrosis, more expressive than
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