Lipid modifications of proteins – slipping in and out of membranes

摘要: Abstract Protein lipid modification, once thought to act as a stable membrane anchor for soluble proteins, is now attracting more widespread attention its emerging role in diverse signaling pathways and regulatory mechanisms. Most multicellular organisms have recruited specific types of lipids suite unique enzymes catalyze the modification select number many which are evolutionarily conserved plants, animals fungi. Each three known – palmitoylation, myristylation prenylation allows cells target proteins plasma membrane, well other subcellular compartments. Among modifications, protein might also function relay between cytoplasmic isoprene biosynthesis that control cell cycle growth. Molecular genetic studies an Arabidopsis mutant lacks farnesyl transferase suggest enzyme has abscisic acid during seed germination stomata. It becoming clear modifications not just fat protein, but part highly intricate network plays coordinating complex cellular functions.