In vitro activity of artemisinin derivatives against African isolates and clones of Plasmodium falciparum.

摘要: The in vitro activities of chloroquine, quinine, mefloquine, halofantrine, artemisinin, arteether, artemether, and artelinate were evaluated against African clones isolates Plasmodium falciparum, using an isotopic, semimicro, drug susceptibility test. chloroquine-resistant FCM 29 clone was 1.6 6.2 times more susceptible to artemisinin when compared with the chloroquine-susceptible, mefloquine-, halofantrine-resistant L-3 L-16 clones, respectively. Cross-resistance patterns between standard antimalarial drugs determined 36 P. falciparum obtained from imported cases malaria France. Chloroquine-resistant (n = 21) significantly (50% inhibitory concentration [IC50] 7.67 nM), arteether (IC50 3.88 artemether 3.71 3.46 as 15 chloroquine-susceptible 11.4, 5.66, 5.14, 5.04 nM, respectively). Arteether, equally effective twice potent artemisinin. A significant positive correlation found mefloquine (r 0.424, P 0.022), halofantrine 0.569, < 0.001), chloroquine quinine 0.651, 0.863, suggesting cross-resistance among these drugs. present findings require confirmation clinical studies.