A network of interactions among seminal proteins underlies the long-term postmating response in Drosophila.

摘要: Despite the importance of seminal proteins in fertility and their capacity to alter mated females' physiology, molecular pathways networks through which they act have not been well characterized. Drosophila fluid includes that fall into biochemical classes conserved from insects mammals, making it an excellent model with address this question. also contains a "sex peptide" (SP, Acp70A) plays major role regulating egg production mating behavior females for several days after mating. This long-term postmating response (LTR) initially requires association SP sperm. The LTR members protein (two lectins, protease, cysteine-rich secretory protein). Here, we show these function interdependently, three-step cascade (first, at level transfer female; second, stability; third, localization within females), leading normal sperm-storage organs. is, turn, necessary successful induction LTR. requirements manifestation establish paradigm multiple can exert actions multistep, multicomponent network interactions.