Central apelin-13 inhibits food intake via the CRF receptor in mice.
作者： Shuang-Yu Lv , Yan-Jie Yang , Yao-Jun Qin , Jia-Run Mo , Ning-Bo Wang
DOI: 10.1016/J.PEPTIDES.2011.11.011
关键词: CRF Receptor 、 Apelin 、 Endocrinology 、 Period (gene) 、 Food intake 、 Vasopressin 、 Receptor 、 Chemistry 、 Inhibitory effect 、 Receptor antagonist 、 Internal medicine
摘要: Apelin, the novel identified peptide, is endogenous ligand for APJ. Previous studies have reported effect of apelin on food intake, however action acute central injected intake in mice remains unknown. The present study was designed to investigate mechanism as well apelin-13 mice. During dark period, cumulative significantly decreased at 4h after intracerebroventricular (i.c.v.) injection 1 and 3 mu g/mouse period reduced during 2-4 h treatment. In fasted mice, 2 apelin-13. water by (3 g/mouse) 4 freely feeding However, light had no influence APJ receptor antagonist apelin-13(F13A) (6 corticotrophin-releasing factor (CRF) a-helical CRF9-41 could reverse inhibitory intake/0-4 induced whereas anorexic not be antagonized arginie vasopressin (AVP) deamino(CH2)(5)Tyr(Me)AVP (0.5 g/mouse). Taken together, these results suggest that inhibits it seems CRF receptor, but AVP might involved this process. (C) 2011 Elsevier Inc. All rights reserved.
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