Estradiol and progesterone binding in uterine leiomyomata and in normal uterine tissues.

摘要: To explain the sensitivity of uterine leiomyomata to endogenous and exogenous estrogens, specific cytosol receptor proteins for estradiol-17 beta progesterone were found in tissue from compared with concentrations receptors normal myometrium endometrium same patient. The concentration cytoplasmic estrogen (40.5 +/- 7.6 fmole/mg proteins, mean SEM) was significantly greater than that (16.5 1.5) less (131 15.1). (104.4 41.2 protein, also (80.8 29.9) (194.7 5.5); however, individual variation precluded statistical significance. presence myomatous tissues explains leiomyoma or steroids may provide information useful clinical management this neoplastic disorder.