Tonic inhibition of striatal dopamine transmission: effects of benzodiazepine and GABAA receptor antagonists on extracellular dopamine levels.
作者： Rand J. Gruen , Arnold J. Friedhoff , Anne Coale , Bita Moghaddam
DOI: 10.1016/0006-8993(92)90851-Y
关键词: GABAA receptor 、 Receptor antagonist 、 Microdialysis 、 Dopamine 、 GABA receptor complex 、 Agonist 、 Biology 、 Internal medicine 、 Antagonist 、 Benzodiazepine 、 Endocrinology
摘要: At present, it is unclear whether ligands which bind at the benzodiazepine/GABA receptor complex play a tonic modulatory role with regard to striatal dopamine (DA) transmission. The present study was designed examine effects of Ro15-1788, benzodiazepine (BZ) antagonist, and SR 95531, GABAA on extracellular DA (DA[e]) concentrations in anesthetized awake rats using technique vivo microdialysis. Local administration Ro15-1788 resulted dose-dependent increase DA[e] both animals. Ro15-1788-induced blocked by coadministration BZ agonist diazepam, as well GABA. 95531 also alteration levels 95531-induced results suggest that GABA may inhibitory
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