Lessons Learned from the Transgenic Huntington's Disease Rats

摘要: Huntington's disease (HD) is a fatal inherited disorder leading to selective neurodegeneration and neuropsychiatric symptoms. Currently, there no treatment slow down or stop the disease. There also therapy effectively reduce In investigation of novel therapies, different animal models disease, varying from insects nonhuman primates, have been created used. Few years ago, first transgenic rat model HD, carrying truncated huntingtin cDNA fragment with 51 CAG repeats under control native promoter, was introduced. We using this in our research review here experience behavioural, neurophysiological, histopathological phenotype rats relevant literature.