ENAMEL-LIKE ANTIGENS IN HAGFISH: POSSIBLE EVOLUTIONARY SIGNIFICANCE.

摘要: The enamel proteins are a family of acidic glycoproteins which represent two groups polypeptides: (i) amelogenins approximately 10-30 kd (kilodaltons) 80% the total protein in most mammalian species and (ii) enamelins 40-72 -5-20% (Termine et al., 1980; Zeichner-David press). During tooth development, inner epithelial cells organ differentiate into ameloblasts form extracellular matrix (see extensive reviews by Poole, 1967, 1971; Slavkin, 1974; Slavkin 1981). Comparable features morphogenesis differentiation have been described for development Chondrichthyes (Moss, 1968, 1977) as well Teleostei (Shellis, 1975, 1978). It is generally agreed that during terminal ameloblasts, synthesized secreted (Orvig, 1967; Peyer, 1968; To determine function structural roles vertebrate various biochemical comparisons polypeptides made. For part, these emphasized similarities amongst glycoproteins. Partial amino acid sequences several different indicate remarkable homology primary structure when comparing 4-5 with 25-30 (Fukae Fincham Comparative data on compositions sizes principal developing cow, hamster, human, pig sheep show (Fincham 1982). In contrast to reported mammals, very little known about etal., 1980). We begun investigate developmental process formation number vertebrates through use indirect immunofluorescent microscopy biochemistry. Several recent studies rabbit antibodies raised against sources antigenically cross-reactive matrices lower higher including Chondrichthyes, Teleostei, Amphibia, Reptilia Mammalia (Graver 1978; Graham Herold now antimouse amelogenin antisera Pacific hagfish (Eptatretus stoutii). cyclostomes comprise lampreys (or myxinoids), eel-like aquatic vertebrates, considered remaining survivors nearly extinct group agnathan or jawless Paleozoic "fish" ostracoderms (Stensio, Hardisty Potter, Hardisty, Further, possess cartilaginous skeleton not mineralized (Hardisty, Therefore, presence enamel-like antigens outer covering teeth, relatively high molecular weight class Droteins, suggests remark-