Population-Based Patterns of Care in the First-Line Treatment of Patients with Advanced Esophagogastric Adenocarcinoma in Germany

摘要: Background: Randomized studies proved the efficacy of new drugs for systemic treatment advanced gastric cancer in past 5 years. However, little is known about use firstline chemotherapy clinical practice patients with or metastatic adenocarcinoma esophagogastric junction (AEG) and stomach. We investigated temporal trends therapy factors influencing decisions these during a 4-year period. Patients Methods: 1058 (median age 67 years) AEG cancers undergoing were documented Therapiemonitor® 2006–2009. Therapiemonitor collects population-based data regarding strategies. Time drug intensity first-line analyzed entire patient group according to (cut-off 65 Karnofsky performance status (KPS; cut-off 80%). Results: Over time, oxaliplatin docetaxel as well capecitabine increased while cisplatin irinotecan slightly declined. The triplets rose from 10.1% 2006 47.0% 2009. Treatment patterns significantly varied by KPS: Older less likely receive triplets, but tended more often oxaliplatin. Likewise, frequently used KPS Conclusions: A clear tendency towards intensive regimens was observed over time. fit treated preferably monotherapy doublets Oxaliplatin has substantially risen.