Genetic variants of glucose-6-phosphate dehydrogenase in the study of carcinoma of the cervix
作者： James W. Smith , Duane E. Townsend , Robert S. Sparkes
DOI: 10.1002/1097-0142(197108)28:2<529::AID-CNCR2820280235>3.0.CO;2-C
关键词: Carcinoma 、 Carcinoma in situ 、 Pathology 、 Glucose-6-phosphate dehydrogenase 、 Dysplasia 、 Cell 、 Medicine 、 Cervix 、 Radiation therapy 、 Disease 、 Cancer research 、 Oncology
摘要: Electrophoretic variants of the X-linked enzyme glucose-6-phosphate dehydrogenase were used to study possible single cell or multicellular origin human cervical neoplasia. Normal and affected tissue from Negro women with dysplasia, carcinoma in situ, invasive evaluated. The results pre-invasive disease consistent a origin. Findings five patients are compatible unicellular origin, while two seems likely. This raises possibility heterogeneous etiology epidermoid carcinoma. Sequential studies one patient carcinoma, studied undergoing radiation therapy, suggest utility G-6-PD electrophoresis for determining effectiveness progress treatment.
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