Hemopexin in severe inflammation and infection: mouse models and human diseases

摘要: Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients sepsis. Extracellular and secondarily released heme amplify inflammation the presence of microbial TLR ligands and/or endogenous mediators. Hemopexin, a protein that binds extraordinary affinity, blocks these effects has been proposed as possible treatment approach to decrease critically ill patients. Methods: We studied mouse models endotoxemia, burn wound infections peritonitis order assess if repletion strategy for hemopexin might be reasonable. also measured small numbers three patient populations logical groups therapy: sepsis ARDS, severe burns, premature infants. Results: Despite disease, mean levels were increased above baseline each murine model. However, decreased or markedly many populations. Conclusions: Potentially different behavior mice humans may important consider when utilizing represent acute human inflammatory diseases which plays role. The findings raise possibility could result insufficiently neutralized cleared some infants who candidates benefit from administration.