Effects of neonatal cholinergic basal forebrainlesions on excitatory amino acid receptors in neocortex

摘要: Abstract The role of cholinergic basal forebrain projections in the modulation corticalplasticity and associated functional changes is currently subject renewed attention.Excitatory amino acid receptors have been identified as mediators cortical topographic efferentand afferent information. In addition some these receptors, notably NMDA andmetabotropic [mGluR] type, participate plasticity. Growing evidence suggests thatinteractions between glutamatergic systems contribute to cognitive corticalfunctions their anatomical physiological substrates. Though glutamatergicmechanisms both shown be involved morphogenesis, few studies haveattempted study interactions development. present investigates effect ofneonatal lesions on NMDA, AMPA mGluR inBALB/CByJ mice, at two different developmental ages. We demonstrated previously that nBMlesions birth result transient depletion for first postnatal weeks,substantial morphogenetic alterations neocortex deficits by adulthood. showhere unilateral neonatal decreases butincreases mGluRs during second week (PND 14). At 30 days postnatal, lesionmediated were attenuated, compared with PND 14, but significant sex differences incontrol nBM lesioned mice apparent. These data support notion thatcholinergic/glutamatergic are important early morphogenesis.Moreover, our results highlight fact well developmentalmechanisms sexually dimorphic.