Cardiorespiratory effects and efficacy of morphine sulfate in winter flounder (Pseudopleuronectes americanus).
作者： Nathalie C. Newby , A. Kurt Gamperl , E. Don Stevens
关键词: Chemistry 、 Morphine 、 Respiration 、 Winter flounder 、 Anesthesia 、 Saline 、 Pseudopleuronectes 、 Flounder 、 Cardiac output 、 Endocrinology 、 Noxious stimulus 、 Internal medicine
摘要: Objective—To assess the cardiorespiratory effects of morphine sulfate and evaluate whether blocks cardiac responses to a noxious stimulus in winter flounder. Animals—42 flounder (Pseudopleuronectes americanus) that were acclimated at 10°C. Procedures—Each fish was fitted with Doppler flow probe around ventral aorta; cannulae placed for injection drug or saline (0.9% NaCl) solution assessments respiration. Selected variables measured morphine-injected (40 mg/kg, IP [n = 18] 17 IV [2]) solution–injected (1.6 mL [22]) various intervals. Heart rate output (CO) also injected (n 19) (10) received innocuous (injection 5% acetic acid SC into cheek) 50 minutes later. Results—Morphine administration promptly induced marked bradycardia (and concomitant reduction CO), followed by prolonged (>...
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