Impaired functional capacity in potential liver transplant candidates predicts short-term mortality before transplantation.

摘要: Liver transplantation (LT) is a lifesaving treatment. Because of the shortage donor organs, some patients will not survive long enough to receive transplant. The identification LT candidates at increased risk short-term mortality without may affect listing decisions. Functional capacity, determined with cardiopulmonary exercise testing (CPET), measure cardiorespiratory reserve and predicts perioperative outcomes. This study examined association between functional capacity survival before potential for CPET predict 90-day transplantation. A total 176 who were assessed nonacute underwent CPET. Ninety days after assessment, 10 164 had undergone deceased (mortality rate = 6.1%). According comparison survivors nonsurvivors, Model End-Stage Disease score, UK (UKELD) age, anaerobic threshold, peak oxygen uptake (VO2) significant univariate predictors transplantation, but only UKELD score VO2 retained significance in multivariate analysis. mean was significantly lower nonsurvivors versus (15.2 ± 3.3 21.2 ± 5.3 mL/minute/kg, P   17.6 mL/minute/kg died (P = 0.03). In conclusion, an impaired have poorer survival; this particularly true individuals worse liver disease severity. Transpl 20:1081–1088, 2014. © 2014 AASLD.