Pharmacokinetics of Tocolytic Agents

摘要: Tocolytic agents are drugs designed to inhibit contractions of myometrial smooth muscle cells. Such an effect has been demonstrated in vitro or vivo for several pharmacological agents, including β-adrenergic agonists, calcium channel antagonists, oxytocin NSAIDs and magnesium sulfate. However, the aim tocolysis is not only stop uterine prevent preterm delivery, but perinatal morbidity mortality associated with birth. The achievement this goal yet clearly any available, use tocolytic may appear controversial. Therefore, it important avoid maternal fetal toxicity when used. During pregnancy, all steps drug pharmacokinetics altered. Absorption administered orally limited because delayed stomach emptying reduced intestinal motility. volume distribution increased. metabolic activity liver increased, accelerating metabolism lipophilic drugs. Renal filtration leading enhanced renal elimination water-soluble These modifications generally responsible plasma concentration half-life most specific have be taken into account using a pregnant women. review provide reader data about currently used treat labour. women affect choice optimal dosage route administration.