Applications of single-chain variable fragment antibodies in therapeutics and diagnostics

作者: Nina E. Weisser , J. Christopher Hall

DOI: 10.1016/J.BIOTECHADV.2009.04.004

关键词: RabComputational biologyAntigen bindingAntibodySingle-chain variable fragmentNanotechnologyAntibody expressionMonoclonalBiologyRecombinant DNA

摘要: … multimers and conjugate Abs will be covered in this review. … scFvs with higher affinities can be isolated by ribosome display. In … The intracellular signaling domains can be comprised of …

参考文章(240)
KA Chester, A Huhalov, Engineered single chain antibody fragments for radioimmunotherapy. Quarterly Journal of Nuclear Medicine and Molecular Imaging. ,vol. 48, pp. 279- 288 ,(2004)
Z. Eshhar, The T-Body Approach: Redirecting T Cells with Antibody Specificity Therapeutic Antibodies. ,vol. 181, pp. 329- 342 ,(2008) , 10.1007/978-3-540-73259-4_14
Viktor Menart, Vladka Gaberc-Porekar, Barbara Podobnik, Irena Zore, Obstacles and pitfalls in the PEGylation of therapeutic proteins. Current Opinion in Drug Discovery & Development. ,vol. 11, pp. 242- 250 ,(2008)
Nadia Ram, Marta Ayala, Damaryst Lorenzo, Daniel Palenzuela, Lissett Herrera, Vivian Doreste, Marlene Pérez, Jorge V. Gavilondo, Pedro Oramas, Expression of a single-chain Fv antibody fragment specific for the Hepatitis B surface antigen in transgenic tobacco plants Transgenic Research. ,vol. 11, pp. 61- 64 ,(2002) , 10.1023/A:1013967705337
E. N. Anderson, Hudson et al. Journal of California Anthropology, The. ,vol. 4, ,(1977)
Hennie R. Hoogenboom, Greg Winter, By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro. Journal of Molecular Biology. ,vol. 227, pp. 381- 388 ,(1992) , 10.1016/0022-2836(92)90894-P
Esther M. Yoo, Letitia A. Wims, Lisa A. Chan, Sherie L. Morrison, Human IgG2 Can Form Covalent Dimers The Journal of Immunology. ,vol. 170, pp. 3134- 3138 ,(2003) , 10.4049/JIMMUNOL.170.6.3134
W.D. Mallender, E.W. Voss, Construction, expression, and activity of a bivalent bispecific single-chain antibody. Journal of Biological Chemistry. ,vol. 269, pp. 199- 206 ,(1994) , 10.1016/S0021-9258(17)42334-9
Hyouk Joung, Kinarm Ko, Kisung Ko, Young-Kug Choo, Mi-Hyun Ahn, Hyun Soon Kim, Mira Song, Glyco-engineering of biotherapeutic proteins in plants. Molecules and Cells. ,vol. 25, pp. 494- 503 ,(2008)