Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats.

摘要: Cyclosporin A (CS-A), a selective inhibitor of T lymphocytes, is reported here to prevent S antigen (S-Ag) induced uveitis in Lewis rats. The S-Ag, found all mammalian retinas, uveitogenic under experimental conditions and patients with certain uveitic entities demonstrate cell mediated responses this antigen. Daily treatment CS-A (10 mg/kg) begun on the same day as S-Ag immunization totally inhibited development autoimmune model. Moreover greater dose (40 efficiently prevented disease process when therapy was started 7 d after immunization. Anti-S-Ag antibody titers were observed be similar rats either protected or not CS-A. Our data support strongly need for participation Since ocular inflammatory an important cause visual impairment, further suggest that may useful intractable uveitis.