Inherited genetic variant predisposes to aggressive but not indolent prostate cancer
作者： Jianfeng Xu , Siqun Lilly Zheng , Sarah D. Isaacs , Kathleen E. Wiley , Fredrik Wiklund
关键词: Immunology 、 SNP 、 Cancer 、 Internal medicine 、 Oncology 、 Prostate cancer 、 Overdiagnosis 、 Allele frequency 、 Disease 、 Single-nucleotide polymorphism 、 Medicine 、 Genotype
摘要: Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset PCa is aggressive accounts for more than 27,000 deaths in the United States annually. Identification factors specifically associated with risk urgently needed to reduce overdiagnosis overtreatment this common disease. To search such factors, we compared frequencies SNPs among patients who were defined having either or less disease four populations examined Genetic Markers Susceptibility (CGEMS) study performed by National Cancer Institute. showing possible associations severity further evaluated an additional three independent from Sweden. In total, studied 4,829 12,205 disease, respectively. We found frequency TT genotype SNP rs4054823 at 17p12 was consistently higher each seven studied, overall P value 2.1 × 10−8 under recessive model, exceeding conservative genome-wide significance level. The difference largest between high-grade, non–organ-confined those low-grade, organ-confined This demonstrates inherited variants predisposing but not exist genome, suggests clinical potential early markers should evaluated.
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