Paraneoplastic movement disorders

摘要: Paraneoplastic movement disorders are rare autoimmune nonmetastatic complications of cancer. Common paraneoplastic include cerebellar syndrome, opsoclonus myoclonus, basal ganglia disorders, stiff person and neuromyotonia. Syndromes usually present before cancer diagnosis commonly associated with one or more serum antibodies. Increasing numbers antibodies have been identified (Hu, Yo, Ri, CV2, amphiphysin, Ma, Ta, Tr, NMDA, mGluR1, PCA2, ANNA-3, VGCCA). Antibodies highly correlated the likelihood an underlying closely certain tumors. Clinical clues to aetiology speed onset, severity, progression, resistance treatment, widespread neurological signs than would expect from nonparaneoplastic aetiologies. Cancer should be sought in those classical presentations possible who If no tumor is found on initial investigation, interval screening advisable. The most common cancers small cell lung cancer, breast, gynaecological, testicular, lymphoma, thymoma. Early identification treatment sometimes leads improvement may improve prognosis. Prognosis dependent type its likely response treatment.