Transluminal angioplasty: a mechanical-pathophysiological correlation of its physical mechanisms.

摘要: We quantitatively determined the relative contribution of various factors leading to arterial lumen enlargement during transluminal angioplasty. Mechanical tests were conducted on both normal and atherosclerotic artery necropsy specimens. In our range dilating pressures (0-3.4 atm or 0-50 lb/in2), content extrusion fluid from plaque accounted for 6-12% overall area increase, while compaction only 1-1.5%. The majority 86.8-93%, was due wall disruption. mechanism disruption began with shearing underlying at relatively low continued longitudinal tearing stretching higher pressures. Diseased arteries dilated significantly more than nondiseased greater equal 1.36 20 lb/in2 (P less .05). stenoses that tested (10-50%), mean pressure required increase cross-sectional by 50% approximately 1.5 22 lb/in2.