Methylation effects on the microdomain structures of phosphatidylethanolamine monolayers

作者: Hao Yu , Sek-Wen Hui

DOI: 10.1016/0009-3084(92)90055-T

关键词: PhosphatidylethanolamineBranching (polymer chemistry)MonolayerPhospholipidPhosphatidylcholineLipid microdomainMoleculeCrystallographyChemistryMethylationStereochemistry

摘要: Abstract Increasing methylation of the headgroup in DPPE results an increase minimum area per molecule highly compressed monolayers at air-water interface. The shape solid domains, as observed by epifluorescence microscopy, also exhibits marked changes upon increasing methylation. Branching domains are and DP(Me)PE, whereas U-shaped or round DP(Me) 2 PE DPPC under our experimental conditions. domain is determined more than corresponding shift critical temperatures, shown study PCs different acyl chain moieties. In mixed lipid monolayers, PC (phosphatidylcholine) (phosphatidylethanolamine) do not mix ideally, indicated non-linear variation average with composition, distinct shapes LE/LC (liquid expanded/liquid condensed) coexisting phases representing PE-enriched PC-enriched those monolayers.

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