NF-kappaB activation and inhibition: a review.

作者: Zhengwu Sun , Roland Andersson

DOI: 10.1097/00024382-200208000-00001

关键词: Cell adhesion moleculeCell biologyImmunologyGeneBiologyKnockout mousePromoterTranscription (biology)Transcription factorProgrammed cell deathSignal transduction

摘要: Among transcriptional regulatory proteins described, NF-kappaB seems particularly important in modulating the expression of immunoregulatory genes relevant critical illness, inflammatory diseases, apoptosis, and cancer. In particular, plays a central role regulating transcription cytokines, adhesion molecules, other mediators. The biochemical basis by which diverse stimuli converge to activate or intervene this family factors is still largely unknown. factor represents an group regulators broad range involved cellular responses kinds signals. Knockout mouse studies have also revealed key for physiological processes, including immune function metabolism. Overall, specificity exist each complex gene function. Each displays distinct affinities different DNA-binding sites present promoters NF-kappaB-regulated genes, may contribute some exhibited. identification specific components signal transduction pathway provides opportunity define mechanisms at level members are activated. Furthermore, identify targets selective inhibition promotion functions. Further will be required elucidate selectivity function, as well its prior potential clinical application.

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