Prophylactic and therapeutic treatment of graft-versus-host disease in Japan

摘要: Allogeneic hematopoietic stem cell transplantation in Japan is very different from that Western countries terms of the homogeneous genetic background, preference for bone marrow to peripheral blood cells, use a single unit cord transplantation, and frequent non-myeloablative preconditioning due large number elderly patients. Therefore, conclusions obtained well-designed prospective and/or comparative studies treatment graft-versus-host disease (GVHD) performed United States or Europe may not fit Japanese transplant This article reviews prophylactic therapeutic acute chronic GVHD have been conducted Japan. A randomized study demonstrated lower incidence tacrolimus-based prophylaxis than cyclosporine A-based prophylaxis. Retrospective non-randomized suggest regimens are well researched nearly optimized patients, including infusion methods target concentration. However, most other were institute small resulting biased conclusions. There no conclusive report on steroid-refractory GVHD. review provides baseline starting create new evidence