PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

Laura Pasqualucci, Peter Neumeister, Tina Goossens, Gouri Nanjangud, R. S. K. Chaganti, Ralf Küppers, Riccardo Dalla-Favera, Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas Nature. ,vol. 412, pp. 341- 346 ,(2001) , 10.1038/35085588

Elias Campo, N Lee Harris, Elaine S Jaffe, Stefano A Pileri, Harald Stein, Jurgen Thiele, James W Vardiman, None, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues ,(2017)

Takahiro Shirogane, Toshiyuki Fukada, Joyce M.M Muller, David T Shima, Masahiko Hibi, Toshio Hirano, Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity. ,vol. 11, pp. 709- 719 ,(1999) , 10.1016/S1074-7613(00)80145-4

Malte Bachmann, Hanjo Hennemann, Pei Xiang Xing, Ingrid Hoffmann, Tarik Möröy, The Oncogenic Serine/Threonine Kinase Pim-1 Phosphorylates and Inhibits the Activity of Cdc25C-associated Kinase 1 (C-TAK1) A NOVEL ROLE FOR Pim-1 AT THE G2/M CELL CYCLE CHECKPOINT Journal of Biological Chemistry. ,vol. 279, pp. 48319- 48328 ,(2004) , 10.1074/JBC.M404440200

John A Muraski, Marcello Rota, Yu Misao, Jenna Fransioli, Christopher Cottage, Natalie Gude, Grazia Esposito, Francesca Delucchi, Michael Arcarese, Roberto Alvarez, Sailay Siddiqi, Gregory N Emmanuel, Weitao Wu, Kimberlee Fischer, Joshua J Martindale, Christopher C Glembotski, Annarosa Leri, Jan Kajstura, Nancy Magnuson, Anton Berns, Remus M Beretta, Steven R Houser, Erik M Schaefer, Piero Anversa, Mark A Sussman, Pim-1 regulates cardiomyocyte survival downstream of Akt Nature Medicine. ,vol. 13, pp. 1467- 1475 ,(2007) , 10.1038/NM1671

R. Amson, F. Sigaux, S. Przedborski, G. Flandrin, D. Givol, A. Telerman, The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 8857- 8861 ,(1989) , 10.1073/PNAS.86.22.8857

E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25

Carolin Reiser-Erkan, Mert Erkan, Zheng Pan, Sandor Bekasi, Nathalia A. Giese, Sylvia Streit, Christoph W. Michalski, Helmut Friess, Jörg Kleeff, Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma. Cancer Biology & Therapy. ,vol. 7, pp. 1352- 1359 ,(2008) , 10.4161/CBT.7.9.6418

Harald Mikkers, John Allen, Puck Knipscheer, Lieke Romeyn, Augustinus Hart, Edwin Vink, Anton Berns, High-throughput retroviral tagging to identify components of specific signaling pathways in cancer Nature Genetics. ,vol. 32, pp. 153- 159 ,(2002) , 10.1038/NG950

Ying-Wei Lin, Zanna M. Beharry, Elizabeth G. Hill, Jin H. Song, Wenxue Wang, Zuping Xia, Zhenhua Zhang, Peter D. Aplan, Jon C. Aster, Charles D. Smith, Andrew S. Kraft, A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma Blood. ,vol. 115, pp. 824- 833 ,(2010) , 10.1182/BLOOD-2009-07-233445