A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study.
作者： Katherine E. Warren , Sri Gururangan , J. Russell Geyer , Roger E. McLendon , Tina Young Poussaint
DOI: 10.1007/S11060-011-0709-Z
关键词: Temozolomide 、 Pediatric Brain Tumor Consortium 、 Medicine 、 Surgery 、 Internal medicine 、 Oncology 、 Glioma 、 Brainstem glioma 、 Cohort 、 Dacarbazine 、 Phases of clinical research 、 Retrospective cohort study
摘要: To estimate the sustained (≥8 weeks) objective response rate in pediatric patients with recurrent or progressive high-grade gliomas (HGG, Stratum A) brainstem (BSG, B) treated combination of O6-benzylguanine (O6BG) and temozolomide® (TMZ). Patients received O6BG 120 mg/m2/d IV followed by TMZ 75 orally daily for 5 consecutive days each 28-day course. The target to consider active was 17%. A two-stage design employed. Forty-three were enrolled; 41 evaluable response, including 25 HGG 16 BSG. tolerable, primary toxicities myelosuppression gastrointestinal symptoms. One partial observed cohort; no responses BSG cohort. Long-term (≥6 courses) stable disease (SD) 4 1 patient B. Of long-term SD, 3 underwent central review 2 reclassified as low-grade gliomas. did not achieve activity
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