Lack of Evidence for Neonatal Misoprostol Neurodevelopmental Toxicity in C57BL6/J Mice

摘要: Misoprostol is a synthetic analogue of prostaglandin E1 that administered to women at high doses induce uterine contractions for early pregnancy termination and low aid in cervical priming during labor. Because the known teratogenic effects misoprostol when given gestation its on axonal growth vitro, we examined potential as neurodevelopmental toxicant neonatal C57BL6/J mice. Mice were injected subcutaneously (s.c.) with 0.4, 4 or 40 µg/kg postnatal day 7, approximate developmental stage mice human birth, after which somatic growth, sensory motor system development assessed. These selected span range exposure used In addition, adult underwent battery behavioral tests relevant disorders such autism including anxiety, stereotyped behaviors, social communication interactions, learning memory. No significant found any measure endpoints. conclusion, results present study C57BL/6J do not provide support toxicity administration approximating timed coincide birth.