Chapter IX Response of nitric oxide synthase to neuronal injury

作者: W. Wu

DOI: 10.1016/S0924-8196(00)80063-9

关键词: Nervous systemNeuroscienceRegeneration (biology)Central nervous systemImmediate early geneNitric oxide synthasePeripheral nervous systemBiologyChemical InjuryNeurotrophin

摘要: Publisher Summary This chapter discusses the changes of nitric oxide synthase (NOS) expression in response to neuronal injury. Up-regulation and de novo expressions NOS different regions nervous system from species animals various ages are reviewed chapter. The regulation potential roles injury-induced degeneration regeneration also discussed its injuries vivo models. Injury-induced is observed many populations neurons central peripheral following types injuries, including axonal injury, ischemichypoxic excitotoxic chemical has been shown be co-expressed with some other injury-related genes, such as immediate early gene (IEG), beta-amyloid precursor protein (APP), neurotrophin receptor genes. can regulated by experimental manipulations, which turn affects survival injured neurons. appears play a double-edged role Whether NO/NOS beneficial or not for depends on isoform, groups neurons, age animal, stage

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