Local Zones of Endoplasmic Reticulum Complexity Confine Cargo in Neuronal Dendrites
作者： Tingting Cui-Wang , Cyril Hanus , Tao Cui , Thomas Helton , Jennifer Bourne
DOI: 10.1016/J.CELL.2011.11.056
关键词: Cell biology 、 Metabotropic glutamate receptor 、 Membrane protein 、 Endoplasmic reticulum 、 Dendritic branch 、 Protein kinase C 、 Glutamate receptor 、 Dendritic spine 、 Integral membrane protein 、 Biology
摘要: Following synthesis, integral membrane proteins dwell in the endoplasmic reticulum (ER) for variable periods that are typically rate limiting plasma delivery. In neurons, ER extends hundreds of microns as an anastomosing network throughout highly branched dendrites. However, little is known about mobility, spatial scales, or dynamic regulation cargo dendritic ER. Here, we show proteins, including AMPA-type glutamate receptors, rapidly diffuse within continuous but confined by increased complexity at branch points and near spines. The range receptor mobility restricted type I mGluR signaling through a mechanism involving protein kinase C (PKC) CLIMP63. Moreover, local zones compartmentalize export correspond to sites new branches. Thus, control spatially scales secretory trafficking elaborate arbors.
elsevier.com
core.ac.uk 
sci-hub.se 参考文章(57)
Alejandra Gardiol, Claudia Racca, Antoine Triller, Dendritic and Postsynaptic Protein Synthetic Machinery The Journal of Neuroscience. ,vol. 19, pp. 168- 179 ,(1999) , 10.1523/JNEUROSCI.19-01-00168.1999
Cécile Vedrenne, Hans-Peter Hauri, Morphogenesis of the endoplasmic reticulum: beyond active membrane expansion. Traffic. ,vol. 7, pp. 639- 646 ,(2006) , 10.1111/J.1600-0854.2006.00419.X
Keisuke Tsuzuki, Bertrand Lambolez, Jean Rossier, Seiji Ozawa, Absolute quantification of AMPA receptor subunit mRNAs in single hippocampal neurons Journal of Neurochemistry. ,vol. 77, pp. 1650- 1659 ,(2001) , 10.1046/J.1471-4159.2001.00388.X
T. Bachi, A. Schweizer, G. Griffiths, H.P. Hauri, M. Ericsson, Characterization of a novel 63 kDa membrane protein. Implications for the organization of the ER-to-Golgi pathway Journal of Cell Science. ,vol. 104, pp. 671- 683 ,(1993)
Nelson Spruston, Pyramidal neurons: dendritic structure and synaptic integration Nature Reviews Neuroscience. ,vol. 9, pp. 206- 221 ,(2008) , 10.1038/NRN2286
Manuel Mameli, Bénédicte Balland, Rafael Luján, Christian Lüscher, Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area Science. ,vol. 317, pp. 530- 533 ,(2007) , 10.1126/SCIENCE.1142365
Andrew C Penn, Stephen R Williams, Ingo H Greger, Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum The EMBO Journal. ,vol. 27, pp. 3056- 3068 ,(2008) , 10.1038/EMBOJ.2008.222
Ben NG Giepmans, Stephen R Adams, Mark H Ellisman, Roger Y Tsien, The Fluorescent Toolbox for Assessing Protein Location and Function Science. ,vol. 312, pp. 217- 224 ,(2006) , 10.1126/SCIENCE.1124618
Sethuraman Sankaranarayanan, Dino De Angelis, James E. Rothman, Timothy A. Ryan, The Use of pHluorins for Optical Measurements of Presynaptic Activity Biophysical Journal. ,vol. 79, pp. 2199- 2208 ,(2000) , 10.1016/S0006-3495(00)76468-X
Attila Losonczy, Judit K. Makara, Jeffrey C. Magee, Compartmentalized dendritic plasticity and input feature storage in neurons Nature. ,vol. 452, pp. 436- 441 ,(2008) , 10.1038/NATURE06725