Roux-en-Y gastric bypass increases systemic but not portal bile acid concentrations by decreasing hepatic bile acid uptake in minipigs

摘要: Roux-en-Y gastric bypass (RYGB) surgery is widely used in the management of morbid obesity. RYGB improves metabolism independently weight loss by still unknown mechanisms. Bile acids (BAs) are good candidates to explain this benefit, since they regulate metabolic homeostasis and their systemic concentrations increase upon RYGB. Here we analyzed mechanisms underlying BA after role liver therein. To aim, Gottingen-like minipig, a human-size mammalian model, which allows continuous sampling simultaneous analysis pre-hepatic portal venous blood. pool composition were measured blood, containing intestinal reabsorbed BAs compared blood during standardized meal test before Systemic total increased RYGB, due an conjugated BAs. Interestingly, ratio portal:systemic decreased indicating for changes. In line, hepatic expression transporter genes Our results show that selective recapture. Thus, alterations function contribute