Cloning and Characterization of IL-1HY2, a Novel Interleukin-1 Family Member

摘要: The interleukin-1 (IL-1) family members play an important role in the process of inflammation and host defense. We describe here identification characterization a novel member IL-1 family, IL-1HY2. human IL-1HY2 protein shares significant amino acid sequence similarity (37%) with receptor antagonist has predicted three-dimensional structure similar to that antagonist. gene is located close proximity other genes on chromosome 2, genomic organization highly conserved members. secreted from mammalian cells, purified recombinant binds soluble type I. expressed skin, spleen, tonsil. Immunohistochemical analysis showed basal epithelia skin proliferating B cells These data suggest it may participate network regulate adapted innate immune responses.