Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives

作者: Uladzimir Bildziukevich , Zülal Özdemir , Zdeněk Wimmer

DOI: 10.3390/MOLECULES24193546

关键词: Antitumor activityADMESupramolecular chemistryCombinatorial chemistryChemistryCalculated dataBetulinic acid

摘要: The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse …

参考文章(72)
Robert J Visalli, Hannah Ziobrowski, Kameswara R Badri, Johnny J He, Xiugen Zhang, Sri Ranjini Arumugam, Hua Zhao, None, Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 3168- 3171 ,(2015) , 10.1016/J.BMCL.2015.05.099
Uladzimir Bildziukevich, Norbert Vida, Lucie Rárová, Milan Kolář, David Šaman, Libor Havlíček, Pavel Drašar, Zdeněk Wimmer, Polyamine derivatives of betulinic acid and β-sitosterol: A comparative investigation. Steroids. ,vol. 100, pp. 27- 35 ,(2015) , 10.1016/J.STEROIDS.2015.04.005
J. Sarek, M. Kvasnica, M. Vlk, M. Urban, P. Dzubak, M. Hajduch, The Potential of Triterpenoids in the Treatment of Melanoma InTech. ,(2011) , 10.5772/19582
Nonappa, David Šaman, Erkki Kolehmainen, Studies on supramolecular gel formation using DOSY NMR Magnetic Resonance in Chemistry. ,vol. 53, pp. 256- 260 ,(2015) , 10.1002/MRC.4185
Edgar Selzer, Christiane Thallinger, Christoph Hoeller, Philipp Oberkleiner, Volker Wacheck, Hubert Pehamberger, Burkhard Jansen, Betulinic acid-induced Mcl-1 expression in human melanoma: mode of action and functional significance Molecular Medicine. ,vol. 8, pp. 877- 884 ,(2002) , 10.1007/BF03402094
David J. Mangelsdorf, Ethan Dmitrovsky, Gordon W. Gribble, Robert A. Maue, Kathleen C. Flanders, Kotha Subbaramaiah, Michael J. Spinella, Carl F. Nathan, Weston W. Porter, William F. Hickey, Donna M. Porter, Anita B. Roberts, Nanjoo Suh, Yongping Wang, Andrew E. Place, Michael B. Sporn, Andrew J. Dannenberg, John J. Letterio, Tadashi Honda, Nanette S. Roche, Lananh Nguyen, Gengfei Wu, Renee F. Ren, Charlotte R. Williams, A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity Cancer Research. ,vol. 59, pp. 336- 341 ,(1999)
Dong-Mei Zhang, Hong-Gui Xu, Lei Wang, Ying-Jie Li, Ping-Hua Sun, Xiao-Ming Wu, Guang-Ji Wang, Wei-Min Chen, Wen-Cai Ye, Betulinic Acid and its Derivatives as Potential Antitumor Agents Medicinal Research Reviews. ,vol. 35, pp. 1127- 1155 ,(2015) , 10.1002/MED.21353
Santanu Kar Mahapatra, Braja Gopal Bag, Parimal Karmakar, Somenath Roy, Sandeep Kumar Dash, Sourav Chattopadhyay, Shib Shankar Dash, Satyajit Tripathy, Balaram Das, Self assembled nano fibers of betulinic acid: A selective inducer for ROS/TNF-alpha pathway mediated leukemic cell death. Bioorganic Chemistry. ,vol. 63, pp. 85- 100 ,(2015) , 10.1016/J.BIOORG.2015.09.006
Mohamed Ali‐Seyed, Ibrahim Jantan, Kavitha Vijayaraghavan, Syed Nasir Abbas Bukhari, None, Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy Chemical Biology & Drug Design. ,vol. 87, pp. 517- 536 ,(2016) , 10.1111/CBDD.12682
Uladzimir Bildziukevich, Lucie Rárová, David Šaman, Libor Havlíček, Pavel Drašar, Zdeněk Wimmer, Amides derived from heteroaromatic amines and selected steryl hemiesters. Steroids. ,vol. 78, pp. 1347- 1352 ,(2013) , 10.1016/J.STEROIDS.2013.10.003