Mechanism of blood coagulation. Newer aspects of anticoagulant and antithrombotic therapy

摘要: Hemostasis as defined by Virchow in the last century is a fine balance between blood flow, humoral factors, and cellular elements of vascular system. Today, biotechnology has advanced our understanding thrombotic process its regulation. Whereas past, heparin warfarin have been sole antithrombotic agents available, specific sites network at both plasmatic can now be targeted. Antibodies against platelet receptors well antithrombin anti-Xa are being developed. Mutations endogenous inhibitors identified causes congenital thrombophilias. The use also advanced. Heparin no longer solely surgical anticoagulant, but used to treat variety conditions including venous thrombosis, unstable angina, myocardial infarction procedures such angioplasty stent implantation. mechanism heparin’s action become more complex with discovery tissue factor pathway inhibitor, selectins, other targets where drug able produce effects.