A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography.

作者: Lili Zhu , Feng Yang , Liqing Chen , Edward J. Meehan , Mingdong Huang

DOI: 10.1016/J.JSB.2007.12.004

关键词: Fatty acid bindingHuman serum albuminDrug interactionDrug Binding SiteBlood serumBinding siteStereochemistryPlasma protein bindingChemistryMechanism of actionBiochemistry

摘要: … subsite on HSA Sudlow site 1 was identified. The presence of fatty acid is needed for the creation of this subsite … Sudlow site 1 can be divided into three subsites: AZT subsite (this study, …

参考文章(52)
Eppler J, Johnson D, Lee S, Klein J, Protein binding of acetylsalicylic acid and salicylic acid in porcine and human serum. Veterinary and Human Toxicology. ,vol. 37, pp. 224- 225 ,(1995)
Vorum H, Reversible ligand binding to human serum albumin. Theoretical and clinical aspects. Danish Medical Bulletin. ,vol. 46, pp. 379- 399 ,(1999)
W. L. Delano, The PyMOL Molecular Graphics System DeLano Scientific. ,(2002)
Arthur A. Spector, [17] Structure and lipid binding properties of serum albumin Methods in Enzymology. ,vol. 128, pp. 320- 339 ,(1986) , 10.1016/0076-6879(86)28077-5
Muhammad Mubashar, Kevin J. Harrington, Khurram S. Chaudhary, Daphne M. Glass, A. Michael Peters, Dudley Sinnett, El Nasir Lalani, Gordon W. Stamp, 99mTc-Sestamibi Imaging in the Assessment of Toremifene as a Modulator of Multidrug Resistance in Patients with Breast Cancer The Journal of Nuclear Medicine. ,vol. 43, pp. 519- 525 ,(2002)
Isabelle Petitpas, Ananyo A. Bhattacharya, Sue Twine, Malcolm East, Stephen Curry, Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin: ANATOMY OF DRUG SITE I * Journal of Biological Chemistry. ,vol. 276, pp. 22804- 22809 ,(2001) , 10.1074/JBC.M100575200
Xiao Min He, Daniel C. Carter, Atomic structure and chemistry of human serum albumin. Nature. ,vol. 358, pp. 209- 215 ,(1992) , 10.1038/358209A0
S Gaudreau, JF Neault, HA Tajmir-Riahi, None, Interaction of AZT with human serum albumin studied by capillary electrophoresis, FTIR and CD spectroscopic methods. Journal of Biomolecular Structure & Dynamics. ,vol. 19, pp. 1007- 1014 ,(2002) , 10.1080/07391102.2002.10506804