Does interferon beta treatment exacerbate neuromyelitis optica spectrum disorder
作者： Su-Hyun Kim , Woojun Kim , Xue Feng Li , In-Ja Jung , Ho Jin Kim
关键词: Spectrum disorder 、 Neuromyelitis optica 、 Retrospective cohort study 、 Expanded Disability Status Scale 、 Immunology 、 Internal medicine 、 Medical record 、 Young adult 、 Multiple sclerosis 、 Medicine 、 Interferon beta
摘要: Objectives:Recent case reports and series have shown that patients with neuromyelitis optica (NMO) experience clinical deterioration under interferon beta (IFN-β) treatment. The objective of the present study was to evaluate whether what extent IFN-β exacerbates NMO spectrum disorders (NMOSD).Methods:We retrospectively reviewed medical records 40 NMOSD who had been treated for more than 6 months whose disease duration 1 year at initiation We evaluated their annualized relapse rates (ARR) Expanded Disability Status Scale (EDSS) scores before after treatment.Results:In total, 95% exhibited an ineffective or exacerbated response treatment mean ARR significantly increased (p = 0.002). > 50% observed in 20 (50%). EDSS score following < 0.001).Conclusion:In patient...
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