Newborn size, infant and childhood growth, and body composition and cardiovascular disease risk factors at the age of 6 years: the Pune Maternal Nutrition Study.

摘要: Objective—To study associations of size and body proportions at birth, growth during infancy childhood, to composition cardiovascular disease (CVD) risk factors the age 6 years. Design—The Pune Maternal Nutrition Study, a prospective population-based maternal nutrition CVD in rural Indian children. Methods—Body measured 698 children years were related from birth. Measurements—Anthropometry was performed every months At years, fat lean mass (DXA) (insulin resistance, blood pressure, glucose tolerance, plasma lipids) measured. Results—Compared with international references (NCHS, WHO) short, light thin (mean weight <-1.0 SD all ages). Larger faster growth, measurements birth predicted higher Weight height more strongly than mass, mid-upper-arm circumference (MUAC) them both approximately equally, skinfolds only mass. Neither birthweight, nor ‘thin-fat’ newborn phenotype, factors. Smaller MUAC insulin resistance (p<0.001) but larger 1 year systolic pressure (p<0.001). After infancy, weight, height, skinfolds, these parameters, associated increased Conclusions—Slower muscle may increase reduce pressure. are adverse childhood factor profile. These growing below ‘norms’ for studies required other populations determine generalisability findings.