The Role of Immunotherapy in the Treatment of Adrenocortical Carcinoma.
作者： Łukasz Obołończyk , Sonia Kaniuka-Jakubowska , Krzysztof Sworczak , Izabela Karwacka
DOI: 10.3390/BIOMEDICINES9020098
关键词: Oncology 、 Radiation therapy 、 Mitotane 、 Medicine 、 Ipilimumab 、 Immunotherapy 、 Pembrolizumab 、 Adrenocortical carcinoma 、 Nivolumab 、 Immune system 、 Internal medicine
摘要: Adrenocortical carcinoma (ACC) is a rare epithelial neoplasm, with high tendency for local invasion and distant metastases, limited treatment options. Surgical the method of choice. For decades, mainstay pharmacological has been adrenolytic drug mitotane, in combination chemotherapy. Immunotherapy latest revolution cancer therapy, however preliminary data single immune checkpoint inhibitors showed modest activity ACC patients. The anti-neoplastic such as anti-cytotoxic-T-lymphocyte-associated-antigen 4 (anti-CTLA-4), anti-programmed death-1 (anti-PD-1), anti-PD-ligand-1 (PD-L1) antibodies different solid tumors aroused interest to explore potential therapeutic effect well. Multiple ongoing clinical trials are currently evaluating role (pembrolizumab, pembrolizumab relacorilant, nivolumab, nivolumab ipilimumab). primary acquired resistance immunotherapy continue counter efficacy. Therefore, attempts made combine therapy: anti-PD-1 antibody anti-CTLA-4 antibody, antagonist glucocorticoid receptor. checkpoints would benefit patients antitumor immunity activated by radiotherapy. well tolerated patients; most frequently observed side effects mild. common adverse skin gastrointestinal disorders. endocrinopathy during anti-CTLA pituitary inflammation thyroid
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