Carbamazepine for cocaine dependence.

摘要: Background Cocaine dependence has become a substantial public health problem, developing significant number of medical, psychological and social problems, including the spread infectious diseases (e.g. AIDS, hepatitis tuberculosis), crime, violence neonatal drug exposure. Although there is no consensus regarding how to treat cocaine dependence, effective pharmacotherapy potentially major role play as part broader treatment milieu. The anti-convulsant carbamazepine, tricyclic medication that widely used variety neurological psychiatric disorders, also been for although its effectiveness not established. Objectives To determine whether carbamazepine (CBZ) dependence. Search strategy We searched: Cochrane Controlled Trials Register (Cochrane Library issue 1, 1999), MEDLINE (from 1966 - October 1997), EMBASE 1980 PsycLIT 1974 July Biological Abstracts LILACS 1982 1997); scan reference list relevant articles; personal communication; conference abstracts; unpublished trials from pharmaceutical industry; book chapters on Selection criteria inclusion all randomised controlled were they should focus use drugs versus placebo patients with additional diagnosis such opiate eligible. Data collection analysis reviewers extracted data independently Odds Ratios, weighted mean difference needed estimated. Qualitative assessments methodology eligible studies carried out using validated checklists. assumed people who died or dropped had improvement tested sensitivity final results this assumption. Where possible was according "intention treat" principles. Main 5 included in review, 455 randomised. No differences found positive urine sample metabolites. Scores Spielberg State Anxiety Inventory slightly favoured but didn't reach statistical significance. Dropouts high both groups up 70% group. Less dropout occurred group (RR 0.87 95%CI 0.71-1.06). When retention due side effects found. participants presenting at least one effect, reported Kranzler (Kranzler 1995), higher 4.33 95% CI 1.45-12.91). Reviewer's conclusions There current evidence supporting clinical CBZ Larger investigation must be considered taking into account these time-consuming efforts reserved medications showing more promising evidence.