Is genetic polymorphism of ER-α, CYP1A1, and CYP1B1 a risk factor for uterine leiomyoma?
作者： Gehan A. El-Shennawy , Abd-Alla A. Elbialy , Anwar E. Isamil , Manal M. El Behery
DOI: 10.1007/S00404-010-1550-X
关键词: Andrology 、 Exon 、 Uterine leiomyoma 、 Allele 、 Gynecology 、 Population study 、 Genotype 、 Case-control study 、 Medicine 、 Restriction fragment length polymorphism 、 Leiomyoma
摘要: Uterine leiomyoma is the most common benign smooth muscle tumor. This study was carried out to evaluate association of ER-α, CYP1A1, and CYP1B1 polymorphisms with uterine in Egyptian women. The population consisted 160 patients 100 healthy women as control. genetic for ER-α MSP1 exon 1, Leu432Val, CYP1A1 Ile462Val were analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) DNA sequencing methods. There no statistically significant differences overall associations between I CT genotypes (P = 0.47). However, an elevated risk observed among AG genotype (P = 0.07) Leu 432Val C/C (P = 0.08). We concluded that carriage CC predict susceptibility they are likely contribute pathogenesis leiomyoma.
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