Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep

摘要: Hepatocyte growth factor (HGF) and vascular endothelial A (VEGFA) are paracrine hormones that mediate communication between pancreatic islet cells (ECs) β-cells. Our objective was to determine the impact of intrauterine restriction (IUGR) on vascularity signaling EC β-cell. Vessel density less in IUGR pancreata than controls. HGF concentrations were also lower EC-conditioned media (ECCM) from IUGR, islets incubated with control ECCM responded by increasing insulin content, which absent ECCM. The effect content blocked an inhibitory anti-HGF antibody. receptor not different islets, but VEGFA high-affinity VEGF higher ECs, respectively. These findings show actions ECs increase secretion diminished. Given potential feed-forward regulation β-cell HGF, these two factors highly integrated normal development, this is decreased fetuses, resulting secretion.