A brominated flame retardant 2,2',4,4' tetrabrominated diphenyl ether (BDE-47) leads to lipogenesis in the copepod Tigriopus japonicus.
作者： Min-Chul Lee , Jeonghoon Han , Seung-Hwi Lee , Duck-Hyun Kim , Hye-Min Kang
DOI: 10.1016/J.AQUATOX.2016.07.002
关键词: Biochemistry 、 Biology 、 Lipid droplet 、 Docosahexaenoic acid 、 Lipogenesis inhibitor 、 Fatty acid 、 Palmitic acid 、 Arachidonic acid 、 Lipogenesis 、 Fatty acid synthesis
摘要: De novo lipogenesis (DNL) is a fatty acid synthesis process that requires several genes, including sterol regulatory element binding protein (SREBP), ATP-citrate lyase (ACLY), and acetyl-CoA carboxylase (ACC). DNL up-regulation able to induce fat accumulation through an increase in acids. To investigate the relationship between of acids lipid droplets response 2,2',4,4' tetrabrominated diphenyl ether (BDE-47), we examined copepod Tigriopus japonicus. Transcription levels DNL-related genes were increased after exposure 2.5μg/L BDE-47 for 24h. After BDE-47, palmitic was significantly (P<0.05) at days 1 4, along with upregulation synthesis-related (e.g., desaturases elongases). However, docosahexaenoic arachidonic down-regulated showing antagonistic effect. Lipid droplet area Nile red staining analysis 24h T. japonicus, while 500μM salicylate (a inhibitor), indicating closely associated this copepod. This study provides better understanding effects on copepods.
sci-hub.se 参考文章(59)
Jeonghoon Han, Eun-Ji Won, Min-Chul Lee, Jung Soo Seo, Su-Jae Lee, Jae-Seong Lee, Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS. Aquatic Toxicology. ,vol. 165, pp. 136- 143 ,(2015) , 10.1016/J.AQUATOX.2015.05.022
Hui-Su Kim, Bo-Young Lee, Eun-Ji Won, Jeonghoon Han, Dae-Sik Hwang, Heum Gi Park, Jae-Seong Lee, Identification of xenobiotic biodegradation and metabolism-related genes in the copepod Tigriopus japonicus whole transcriptome analysis Marine Genomics. ,vol. 24, pp. 207- 208 ,(2015) , 10.1016/J.MARGEN.2015.05.011
Agnes Görlach, Elitsa Y. Dimova, Andreas Petry, Antonio Martínez-Ruiz, Pablo Hernansanz-Agustín, Anabela P. Rolo, Carlos M. Palmeira, Thomas Kietzmann, Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? Redox biology. ,vol. 6, pp. 372- 385 ,(2015) , 10.1016/J.REDOX.2015.08.016
Qiang Gao, Joel M. Goodman, The lipid droplet—a well-connected organelle Frontiers in Cell and Developmental Biology. ,vol. 3, pp. 49- 49 ,(2015) , 10.3389/FCELL.2015.00049
Jente Stel, Juliette Legler, The Role of Epigenetics in the Latent Effects of Early Life Exposure to Obesogenic Endocrine Disrupting Chemicals. Endocrinology. ,vol. 156, pp. 3466- 3472 ,(2015) , 10.1210/EN.2015-1434
Heikki Peltonen, Päivi Ruokojärvi, Markku Korhonen, Hannu Kiviranta, Juha Flinkman, Matti Verta, PCDD/Fs, PCBs and PBDEs in zooplankton in the Baltic Sea - Spatial and temporal shifts in the congener-specific concentrations Chemosphere. ,vol. 114, pp. 172- 180 ,(2014) , 10.1016/J.CHEMOSPHERE.2014.04.026
Nicholas Houstis, Evan D. Rosen, Eric S. Lander, Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. ,vol. 440, pp. 944- 948 ,(2006) , 10.1038/NATURE04634
Sheikh Raisuddin, Kevin W.H. Kwok, Kenneth M.Y. Leung, Daniel Schlenk, Jae-Seong Lee, The copepod Tigriopus: a promising marine model organism for ecotoxicology and environmental genomics. Aquatic Toxicology. ,vol. 83, pp. 161- 173 ,(2007) , 10.1016/J.AQUATOX.2007.04.005
Chang-Bum Jeong, Bo-Mi Kim, Rae-Kwon Kim, Heum Gi Park, Su-Jae Lee, Kyung-Hoon Shin, Kenneth Mei Yee Leung, Jae-Sung Rhee, Jae-Seong Lee, Functional characterization of P-glycoprotein in the intertidal copepod Tigriopus japonicus and its potential role in remediating metal pollution. Aquatic Toxicology. ,vol. 156, pp. 135- 147 ,(2014) , 10.1016/J.AQUATOX.2014.08.005
N. Hastings, M. Agaba, D. R. Tocher, M. J. Leaver, J. R. Dick, J. R. Sargent, A. J. Teale, A vertebrate fatty acid desaturase with Δ5 and Δ6 activities Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 14304- 14309 ,(2001) , 10.1073/PNAS.251516598