CD15 immunostaining improves placental diagnosis of fetal hypoxia

摘要: Abstract Introduction Fetal hypoxic events with unclear predictive value are a common indication for placenta examination. We evaluated whether the use of CD15 immunostaining can improve assessment severity and duration fetal hypoxia. Methods compared placentas (37–42 gestational weeks) from stillborns/newborns birth asphyxia (BA) non-hypoxic newborns. Placental findings were studied in following groups: (1) acute BA (n = 11) due to placental abruption, (2) non-acute (n = 121) conditions, (3) non-BA (n = 46) pregnancies preeclampsia diabetes, (4) controls (n = 30). Results A high expression feto-placental resistance vessels (FRVs) was present (95.9%), but absent BA, (p  Discussion have defined characteristic pattern FRVs that allows interpret various clinical/placental conditions respect hypoxia, an improved predictability conventional analyses. This approach represents novel diagnostic strategy examination, which could indirectly assess intrauterine hypoxia heterogeneous population